Health professionals >
Pulmonary Arterial Hypertension >
Pulmonary Arterial Hypertension
Symptoms and Treatments
Patients diagnosed with pulmonary arterial hypertension should be referred to a pulmonary hypertension center for experienced evaluation and management of this serious scleroderma complication.
|
Action |
Most Common |
|
|
Endothelin Receptor Antagonists |
||
|
Ambrisentan (Volibris®) |
Act on blood vessels |
Peripheral edema, headache, decreased hemoglobin, nasal stuffiness, palpitations. |
|
Bosentan (Tracleer®) |
Act on blood vessels |
Headache, nasal stuffiness, flushing, liver function abnormality, flushing, pulmonary edema, low blood pressure. |
|
Macitan (Opsumit®) |
Act on blood vessels |
Nasal stuffiness, headache, anemia, bronchitis, sore throat, flu. |
|
|
||
| Prostaglandin Derivatives | ||
|
Epoprostenol (Flolan®, Caripul®) |
Act on blood vessels by inhibiting platelet aggregation | Headache, dizziness, flushing, jaw pain, diarrhea, bone pain, potential serious infection associated with central line catheter in the chest wall. |
| Trepostinil (Remodulin®) | Act on blood vessels |
Pain at infusion site, headache, cough, diarrhea, nausea, flushing, jaw pain, skin rash, edema. |
|
|
||
| Calcium Channel Blockers |
||
| Can be helpful to a small proportion of patients; see Raynaud’s section. |
See Raynaud’s section |
See Raynaud’s section |
|
|
||
| Phosphodiesterase Type 5 (PDE5) Inhibitor | ||
| Sildenafil citrate (Revatio®) | Act on blood vessels | Headache, flushing, dyspepsia, flushing, nosebleeds, vision change, nasal stuffiness, diarrhea, insomnia. |
| Tadalafil (Adcirca®) |
Act on blood vessels | Headache, muscle pain, flushing, stomach upset, nausea, respiratory tract infection, nasal stuffiness. |
|
|
||
