{"id":4580,"date":"2016-04-20T18:26:55","date_gmt":"2016-04-20T17:26:55","guid":{"rendered":"http:\/\/dev5.sclerodermie.ca\/?page_id=4580"},"modified":"2016-04-22T20:31:22","modified_gmt":"2016-04-22T19:31:22","slug":"skin-fibrosis","status":"publish","type":"page","link":"http:\/\/dev5.sclerodermie.ca\/en\/health-professionals\/abc-on-symptoms-and-treatments\/skin-fibrosis\/","title":{"rendered":"Skin Fibrosis"},"content":{"rendered":"

Symptoms and Treatments<\/h2>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/td>\n\n

Action<\/strong><\/span><\/p>\n<\/td>\n

\n

Most Common
Side Effects
<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n<\/thead>\n

\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
Immunosuppressants<\/strong><\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
(None proven in controlled trials; the following have been used)<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n

Cyclophosphamide (Procytox\u00ae)
<\/strong><\/p>\n<\/td>\n

Suppress immune response<\/td>\nHair loss, decreased appetite, bladder inflammation, nausea, bone marrow damage, diarrhea, vomiting, mouth sores, increased cancer risk, increased infections.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n

Cyclosporine
(Neoral\u00ae,
Sandimmune\u00ae)<\/p>\n<\/td>\n

Impair lymphocytes<\/td>\nTremor, hypertension, hirsutism, kidney failure, headache, nausea, vomiting, infections.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n

D-penicillamine
(Cuprimine\u00ae)<\/p>\n<\/td>\n

Can inhibit
collagen
cross-linking<\/td>\n		Skin rash, bone marrow damage (rare), diarrhea, impaired taste, kidney damage, mouth sores, nausea.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
Methotrexate<\/td>\nSuppress immune response<\/td>\nDiarrhea, decreased appetite, serum acid uric increased, mouth inflammation, liver and kidney disorder, nausea, mouth sores, skin rash.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n

Mycophenolate mofetil (Cellcept\u00ae)<\/p>\n<\/td>\n

Impair lymphocytes<\/td>\nPain, abdominal pain, back pain, tremor, headache, hypertension, chest pain, GI hemorrhage, nausea, vomiting, anemia, fever, infections, sepsis, swelling in the legs.<\/td>\n<\/tr>\n
\n
\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Scleroderma Medications Guide (Canada)<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Symptoms and Treatments   \u00a0 Action Most CommonSide Effects \u00a0 \u00a0 \u00a0 Immunosuppressants \u00a0 \u00a0 (None proven in controlled trials; the following have been used) \u00a0 \u00a0 Cyclophosphamide (Procytox\u00ae) Suppress immune response Hair loss, decreased appetite, bladder inflammation, nausea, bone marrow damage, diarrhea, vomiting, mouth sores, increased cancer risk, increased infections. \u00a0 \u00a0 \u00a0 Cyclosporine(Neoral\u00ae,Sandimmune\u00ae) […]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":357,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-sclerodermie-quebec.php","meta":[],"acf":[],"yoast_head":"\nSkin Fibrosis - Sclerodermie<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/dev5.sclerodermie.ca\/en\/health-professionals\/abc-on-symptoms-and-treatments\/skin-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Skin Fibrosis - Sclerodermie\" \/>\n<meta property=\"og:description\" content=\"Symptoms and Treatments   \u00a0 Action Most CommonSide Effects \u00a0 \u00a0 \u00a0 Immunosuppressants \u00a0 \u00a0 (None proven in controlled trials; 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